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Artigos científicos

Adult Mesenchymal Stem Cells for Osteoarthritis Therapy

Adult Mesenchymal Stem Cells for Osteoarthritis Therapy

Ulrich Nöth; Andre F. Steinert; Rocky S. Tuan

07/03/2008; Nat Clin Pract Rheumatol. 2008;4(7):371-380. © 2008 Nature Publishing Group

Despite the high prevalence and morbidity of osteoarthritis (OA), an effective treatment for this disease is currently lacking.

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Sobre PRP (Plasma Rico em Plaquetas)

Platelet-rich Plasma: Current Concepts and Application in Sports Medicine

J Am Acad Orthop Surg, Vol 17, No 10, October 2009, 602-608.
© 2009 the American Academy of Orthopaedic Surgeons
This Article
Michael P. Hall, MD, Phillip A. Band, PhD, Robert J. Meislin, MD, Laith M. Jazrawi, MD and Dennis A. Cardone, DO
Orthopaedic Advances articles provide current information on recent developments in orthopaedic surgery, technology, pharmacotherapeutics, and diagnostic modalities.

Platelet-rich plasma is defined as autologous blood with a concentration of platelets above baseline values. Platelet-rich plasma has been used in maxillofacial and plastic surgery since the 1990s; its use in sports medicine is growing given its potential to enhance muscle and tendon healing. In vitro studies suggest that growth factors released by platelets recruit reparative cells and may augment soft-tissue repair. Although minimal clinical evidence is currently available, the use of platelet-rich plasma has increased, given its safety as well as the availability of new devices for outpatient preparation and delivery. Its use in surgery to augment rotator cuff and Achilles tendon repair has also been reported. As the marketing of platelet-rich plasma increases, orthopaedic surgeons must be informed regarding the available preparation devices and their differences. Many controlled clinical trials are under way, but clinical use should be approached cautiously until high-level clinical evidence supporting platelet-rich plasma efficacy is available.

Novos tratamentos

Am J Sports Med 2009;37:571-578.

Bone Marrow Stimulation Aids Repair of Incomplete ACL Tears

By David Douglas

NEW YORK (Reuters Health) Apr 24 - Primary anterior cruciate ligament (ACL) repair combined with bone marrow stimulation helps restore stability and function in youthful athletes with acute incomplete ACL tears, according to Italian researchers.

"Our technique," lead investigator Dr. Alberto Gobbi told Reuters Health, "avoids the use of the patient's own hamstring or patellar tendon to reconstruct the native ACL, eliminating harvest site morbidity. Our goal is to enhance natural healing processes to regenerate the partially torn ACL."

In the March issue of The American Journal of Sports Medicine, Dr. Gobbi and colleagues at Orthopaedic Arthroscopic Surgery International, Milan, observe that standard ACL reconstruction is the conventional method and has about an 80% success rate.

To determine whether ACL repair combined with bone marrow stimulation of the ACL femoral attachment might also be of value, the researchers employed the approach in 26 athletes, ranging in age from 17 to 37 years, with arthroscopically confirmed incomplete ACL proximal tears.

The repair procedure involved suturing of the tear and creation of small holes around the ACL femoral attachment, the idea being to facilitate release of mesenchymal stem cells from the bone marrow in order to promote healing.

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Cientistas desenvolvem nova técnica de tratamento da artrose

Desgaste do tecido cartilaginoso pode levar à artrose, através do uso de células-tronco, pesquisadores da Universidade de Lübeck desenvolvem técnica mais econômica para o tratamento do desgaste das articulações. 

Menos intervenções cirúrgicas e substancial redução de custos são algumas das vantagens da nova técnica desenvolvida pelos pesquisadores da Universidade de Lübeck. Ela visa a reparação do tecido cartilaginoso que reveste as articulações, absorvendo choques e facilitando o deslizamento, e cujo desgaste é responsável pela artrose.

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